Long time no see, sir: Since 5449 is not available now, I am considering a new way to make P2P.
If I start from 14 and add 1:1 phosphoric acid to start the reaction, can I get P2P? Before that, is there anything else I need to do?
Or do I have to add sodium hydroxide solution first, cool and crystallize to get 5449. Then react with phosphoric acid to get P2P?
I have seen another link, and it may be due to translation reasons, the names of many chemical substances are different, and I can't be sure. If you can give me an answer, I would be very grateful!
If I start from 14 and add 1:1 phosphoric acid to start the reaction, can I get P2P? Before that, is there anything else I need to do?
Or do I have to add sodium hydroxide solution first, cool and crystallize to get 5449. Then react with phosphoric acid to get P2P?
I have seen another link, and it may be due to translation reasons, the names of many chemical substances are different, and I can't be sure. If you can give me an answer, I would be very grateful!
- By G.Patton
What is 14? Can you name substances in accordance with IUPAC or their CAS? I don't understand you.
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- By qwe111
Hello Sir:
I successfully made 5449 using the method in the post.
Then I made p2p.
Meth was made using sodium borohydride.
Customers reported that the effect of methamphetamine was very weak.
I want to know why.
The sodium salt obtained by this method was very wet. I had no way to dry it. I only used a Buchner funnel to filter out some of the water. I went directly to the next step of the reaction when the sodium salt was still very wet.
I used a small amount of water to dissolve the sodium salt, and then added 85% phosphoric acid. Probably because the sodium salt was not completely dried and contained a lot of water. The mixture could only be heated to about 100°. The mixture boiled very violently in the reactor. So much so that the coolant refrigeration device of the reflux condenser was heated to 60-70°. It was completely unable to cool a large amount of steam.
After about 6 hours of reflux, the heating was turned off and the mixture was allowed to separate into layers. The P2P obtained looked very dirty. I used steam to distill P2P. The distilled P2P was very yellow in color. In the distillation receiving bottle, P2P floated on the top layer, and the bottom layer was water. After cooling, all P2P was at the bottom layer, and the top layer was water. Does this P2P contain other substances that have not reacted completely? The P2P remaining in the distillation flask is very viscous.
What may be the cause of these problems?
I successfully made 5449 using the method in the post.
Then I made p2p.
Meth was made using sodium borohydride.
Customers reported that the effect of methamphetamine was very weak.
I want to know why.
The sodium salt obtained by this method was very wet. I had no way to dry it. I only used a Buchner funnel to filter out some of the water. I went directly to the next step of the reaction when the sodium salt was still very wet.
I used a small amount of water to dissolve the sodium salt, and then added 85% phosphoric acid. Probably because the sodium salt was not completely dried and contained a lot of water. The mixture could only be heated to about 100°. The mixture boiled very violently in the reactor. So much so that the coolant refrigeration device of the reflux condenser was heated to 60-70°. It was completely unable to cool a large amount of steam.
After about 6 hours of reflux, the heating was turned off and the mixture was allowed to separate into layers. The P2P obtained looked very dirty. I used steam to distill P2P. The distilled P2P was very yellow in color. In the distillation receiving bottle, P2P floated on the top layer, and the bottom layer was water. After cooling, all P2P was at the bottom layer, and the top layer was water. Does this P2P contain other substances that have not reacted completely? The P2P remaining in the distillation flask is very viscous.
What may be the cause of these problems?
- By G.Patton
Hello, your problem not in P2P, as I see. If you get pure P2P after distillation, it can't be reason cuz steam distillation allows to get pure enough P2P for the following synthesis. Probably, you've got racemic methamphetamine which contained more l-meth than d-meth. It can be a reason of it potency.
You may try to separate isomers after next synthesis in accordance forum instructions.
You may try to separate isomers after next synthesis in accordance forum instructions.
- By qwe111
Hi Sir,
Of course I know about racemic and D-meth.
I have done tartaric acid separation of isomers and obtained pure D-meth, but the customer feedback said that the effect was poor.
I used 5449 purchased from the manufacturer before, and the P2P obtained by the reaction was very clean after distillation, almost transparent white.
The D-meth was very effective.
This time all other reagents used were the same, only 5449 was different.
I am not sure whether P2P contains unreacted benzaldehyde or methyl 2-chloropropionate.
I want to try to use other methods to clean P2P to remove the benzaldehyde or methyl 2-chloropropionate contained in it, but so far, I have not found any useful answers.
Sir, do you know any effective methods?
Happy New Year!
Of course I know about racemic and D-meth.
I have done tartaric acid separation of isomers and obtained pure D-meth, but the customer feedback said that the effect was poor.
I used 5449 purchased from the manufacturer before, and the P2P obtained by the reaction was very clean after distillation, almost transparent white.
The D-meth was very effective.
This time all other reagents used were the same, only 5449 was different.
I am not sure whether P2P contains unreacted benzaldehyde or methyl 2-chloropropionate.
I want to try to use other methods to clean P2P to remove the benzaldehyde or methyl 2-chloropropionate contained in it, but so far, I have not found any useful answers.
Sir, do you know any effective methods?
Happy New Year!
- By G.Patton
Hi. Let anyone else check it. Probably it's his subjective opinion.
Distillation is effective enough method. Also, you can use bisulfite purification. But in my opinion, it's excessive and has no reason to do (in your case).
Distillation is effective enough method. Also, you can use bisulfite purification. But in my opinion, it's excessive and has no reason to do (in your case).
