Hello Breaking Bad!
We present to your attention the long-awaited material on the synthesis of the most famous and best synthetic cannabinoid!
The synthesis is very simple from completely legal reagents.
It is also worth noting that you can work in several directions:
- synthesis and sale of semi-finished product (3-(1-Naphthoyl)indole)
- synthesis and sale of JWH-018
- production of smoking blends
In the near future, a video clip will be released on the production of synthetic hashish based on JWH-018, obtained during this work.
Oh, right. I have confused myself, sorry. Sounds correct but I never heard about salt form. Probably steric hurdles prevent this formation. Cl atom is quite large.
Hello Breaking Bad!
We present to your attention the long-awaited material on the synthesis of the most famous and best synthetic cannabinoid!
The synthesis is very simple from completely legal reagents.
It is also worth noting that you can work in several directions:
- synthesis and sale of semi-finished product (3-(1-Naphthoyl)indole)
- synthesis and sale of JWH-018
- production of smoking blends
In the near future, a video clip will be released on the production of synthetic hashish based on JWH-018, obtained during this work.
Oh, right. I have confused myself, sorry. Sounds correct but I never heard about salt form. Probably steric hurdles prevent this formation. Cl atom is quite large.
Hello,
I have a question regarding this synthesis. Why is N1 alkylation of indole performed as a last step. Can we acylate N-alkyl indole in the same C3 manner with specificity?
Thank you,
WoodChipperr.
would this be an option if you have low quality plant material but wish to make it more profitable? or is it very must distinguishable from a cannabis high?
Hi , thank you for the video , just a question what is the HPLC purity % ? (on the video above) ,what do you guys think about this patent purification/recristalization method ?: ! CN102838525A !
1-pentyl-3-(1 naphthoyl) indole bullion
drop into above-mentioned thick wet article in the 120ml methyl alcohol, and temperature rising reflux 1h is cooled to 15 ± 1 ℃, and filtration is watered with cold methanol and to be washed, drain refining wet article 56g; To make with extra care wet article and drop into vacuum rotary furnace drying bipyramid, be evacuated to-0.09Mpa, the logical circulating hot water oven dry of chuck; Water temperature is controlled at 55～60 ℃ of oven dry 7.5h, after offgas duct turns cold, is cooled to 25 ℃ of dischargings; Get 1-pentyl-3-(1 naphthoyl) indole product 51.5g; Yield 94.0%, purity (HPLC): 99.0%, M.P:66.5～67.4 ℃.
would this be an option if you have low quality plant material but wish to make it more profitable? or is it very must distinguishable from a cannabis high?
Well yes, I realize it isn't ethical, and I'm not exactly he'll set on doing it but it's just a hypothetical question. I don't see the harm. In asking tho I understand you don't want to be accosciated with emergency room trips if someone does this. Actually I'm interested in both and if the high is the same would it be detectable in thc urine test?
Well yes, I realize it isn't ethical, and I'm not exactly he'll set on doing it but it's just a hypothetical question. I don't see the harm. In asking tho I understand you don't want to be accosciated with emergency room trips if someone does this. Actually I'm interested in both and if the high is the same would it be detectable in thc urine test?
The high is slightly different although depends on the quantity. Synthetic cannabinoids are way more potent then the plant. I'm pretty sure that yes synthetic cannabinoids are detectable in THC tests because synthetic cannabinoids trigger THC receptors in the brain with release the same metabolites as canabis although this is not applicable by all synthetic cannabinoids. My personal opinion is that drugs should not be associated with money and they should be widely available, so as in for the potential profits out of selling low quality weed laced with synthetic cannabinoids (although unethical) I really don't know.
-WC
I have a question regarding this synthesis. Why is N1 alkylation of indole performed as a last step. Can we acylate N-alkyl indole in the same C3 manner with specificity?
would this be an option if you have low quality plant material but wish to make it more profitable? or is it very must distinguishable from a cannabis high?
Sorry if this isn't the right place to post.
A while ago I tried this synthesis by changing a few reagents:
AlCl3 was replaced by ZnCl2.
TBAB was replaced by DDAC (Didecyldimethylammonium chloride), a phase catalyst found OTC in disinfectants and anti-algae products.
With these changes, the 3-(1-naphthoyl)indole didn't precipitate, and I had to evaporate the DCM for it to precipitate. The 3-(1-naphthoyl)indole obtained was pink/red and my attempts to purify it by recrystallization were unsuccessful. One of the forum experts advised me to make a solution with 10% NaOH in 50:50 water:ethanol for recrystallization, which seemed to work, giving me a beige/white product.
So I moved on to the next stage, using the somewhat impure 3-(1-naphthoyl)indole, but replacing the TBAB with DDAC. The DDAC was obtained by evaporating most of the water found in an anti-algae product containing almost exclusively DDAC. This concentrated aqueous solution of DDAC replaced the TBAB. I might add that this solution contained a small amount of pink dye, which didn't seem to pose any problems for the reaction.
In the end, a yellow product was obtained, which was left in the open air for a few weeks, as a smell of 1-bromopentane could still be detected.
After a few weeks, the smell had disappeared and the product was dark orange, some of the oil having partially crystallized. The melting point corresponded perfectly to JWH-018. Out of curiosity, I even made a Liebermann reagent, which on contact with the substance turned brown, a color that correspond to JWH-018.
(https://en.wikipedia.org/wiki/Liebermann_reagent)
i used benzoyl chloride i tried to make a simpler version the same reaction and it was strange sometimes strong can make you black out sometimes weak what's the problem
Hello, there is no exact time. You need to control the reaction and finish reflux after until the boiling is slowing down. It's noticeable, the bubbles become smaller, the mixture thickens. Approximate range is ~15-40 min.
Hello Breaking Bad!
We present to your attention the long-awaited material on the synthesis of the most famous and best synthetic cannabinoid!
The synthesis is very simple from completely legal reagents.
It is also worth noting that you can work in several directions:
- synthesis and sale of semi-finished product (3-(1-Naphthoyl)indole)
- synthesis and sale of JWH-018
- production of smoking blends
In the near future, a video clip will be released on the production of synthetic hashish based on JWH-018, obtained during this work.
am from a third world country we dont have 1 Naphtoyl Chloride at all we dont even have DMC we have Methyline Chloride , i can only get Naphthalene balls and Aluminim Chloride and Indole , what should i do please advice
am from a third world country we dont have 1 Naphtoyl Chloride at all we dont even have DMC we have Methyline Chloride , i can only get Naphthalene balls and Aluminim Chloride and Indole , what should i do please advice
First of all, hats off to the author
Seeing that some people were skeptical about the final result before, I tested it myself and it definitely works!
But also encountered problems do not know how to solve?
1, the final oil has been in the sun for 3 days and still has the 1-bromopentane smell, I put it on cigarettes and the smell is devastating, looking for a solution!
2, the oily substance and the e-cigarette oil will still be layered after mixing, how can I blend the e-cigarette oil perfectly?
These two issues are bothering me and I'm hoping someone who knows can give me some advice! Thanks a lot!
Eu estou no Brasil e estou com dificuldade de encontrar alguns dos reagentes listados, algum fornecedor confiável em pequenas quantidades pra começar? Aqui o mercado dos canabinoides sintéticos é milionário e gera muito dinheiro, eu tenho rotas de distribuição em quantidades muito grandes, atualmente eu compro o produto de outra pessoa q já vem pronto, mas a qualidade está muito baixa e eu não sei qual o canabinoides usado, eu tenho toda a aparelhagem necessária, só faltam os reagentes, alguém pode me ajudar? No Alibaba só encontrei algumas coisas, e em quantidades mínimas muito grandes pra trazer.
Eu precisava de contato de fornecedores de matéria prima, onde eu moro no Brasil o mercado de canabinoides sintéticos está explodindo, rendendo milhões, e eu tenho muitas rotas de venda em grandes quantidades para distribuir no país todo, se alguém tiver algum fornecedor pra cá, me avisem.
can i use the synthesis of 3-(1 napthoyl) indole to the tobacco? or i must do all the step of JWH-18 synthesis?
can i skip the recrystallization step and jump to synthesis of JWH-18? (because the 10 L flask is very expensive for me) can anyone give me an advice for that problem? thanks
Hello Breaking Bad!
We present to your attention the long-awaited material on the synthesis of the most famous and best synthetic cannabinoid!
The synthesis is very simple from completely legal reagents.
It is also worth noting that you can work in several directions:
- synthesis and sale of semi-finished product (3-(1-Naphthoyl)indole)
- synthesis and sale of JWH-018
- production of smoking blends
In the near future, a video clip will be released on the production of synthetic hashish based on JWH-018, obtained during this work.
Please, formulate your request clearly. I don't understand what do you need from me in accordance with your fragments of phrases. Write me DM please, don't flood by off-top here.
Alguém pode me dizer se essa receita é eficaz? Alguém comentou que fez a mesma coisa e não funcionou. E em nome dos administradores, você pode confirmar que esse método é eficaz, já que eu pedi os ingredientes para fazê-lo.
I have done THE STAGE 3 and the results is like in form of oil,
What should i do to get a liquid so that i can soak my A4 paper in it ?? If possible whats the best solvent should i use ?
Thanks
Stage 3. JWH-018 Synthesis
19. Previously purified 3-(1-naphthoyl)indole 100 g is poured into a flask. 20. Sodium hydroxide 50 g is added. 21. Next, TBAB (tetrabutylammonium bromide) 25 g is added. 22. Water 200 ml is poured into the flask. 23. 1-Bromopentane 75 g is added. 24. A stirrer is turned on. 25. The reaction mixture in the flask is self-heated. An external heating is turned on until the mixture starts to boil. The boiling point is maintained for 15-30 min, depending on a boiling intensity. 26. A 1-bromopentane excess will be evaporated into an atmosphere (use proper ventilation). Reflux condencer is installed. 27. After a while, the mixture is poured into a beaker. The mixture is left for a layers separation. 28. The desired top layer is collected. The collected top layer is transferred into a separate vessel. 29. The oil is cooled down to room temperature (this procedure also helps to evaporate a 1-bromopentane excess if it is still there).
