Cannabidiol (CBD) Isomerization to Psychoactive Cannabinoids

[kitboy]

I was cooking CBD and by mistake added NAoh to the mixture, I think the isomerization stopped. 2 layers were formed, can someone tell me what was formed? Is it a good way to extract THC extract?

I am using methanol and HCL

 

[G.Patton]

Hello, at what stage have you added NaOH?

The answer can be given by HPLC analysis.

 

[kitboy]

After 2 hours of isomerization, an oil was formed but it has an unpleasant smell and I don't know how to purify it.

 

[kitboy]

When adding Naoh, the two phases separated and I think the reaction stopped. I tried to wash it in many ways but I can't get rid of that bad smell.

 

[cvvvxa]

bases convert cbd(thc doesnt get converted) to some quinone derivatives. i belive diffrent solvents can be used to separate it from thc but i cant remember which also in what literature was it described also beacuse its green(i assume) some plant impurites also may be oxidised

 

[kitboy]

What is better acetic acid or hydrochloric acid? I have an oil left with a disgusting smell that I make to clean it or extract the pure cbd loas from methanol

 

[cvvvxa]

room temp toluene and p-toluenesulfonic acid can be used for nearly pure delta 9 and other solvents with heat result in delta 8

 

[cvvvxa]

toluene may be hard to remove but, 44h(48h will result in slightly more conversion but about 10% delta8) stirred 10% ptsa and enough toluene to dissolve it, then workup

 

[kitboy]

When you add water saturated in NAOH to counteract the acid, I cannot eliminate it all, and if I add too much water the upper phase turns black. How can I do the extraction? How do I eliminate the acid smell? I tried cleaning it with distilled water but it didn't work.

I need help with this please

What PH should I leave the THC? Can I use butane or toluene to purify THC?

 

[WillD]

Methods using catalytic amounts acids have established themselves better than in this topic. With pTSA 10% mol in DCM (delta-8) or with HCl 0,05% in ethanol (delta-9)

 

[Dr. MMX]

can be used different alcohol than Ethyl aclohol? maybe ipa instead?
can hcl be used?

 

[Irving Langmuir]

I think so, as long as your reagents are soluble. HCl can be used as an acid catalyst.

 

[WillD]

The change of solvent and the amount of acid greatly changes the composition of the result

 

[kitboy]

I think it is better to use methanol