1-Phenyl-2-propanone (P2P) Leuckart amination to amphetamine and methamphetamine. Smale scale.

[TheNut22]

I made my stonger hydrogen peroxides from 12% H2O2. I just carefully evaporated water from it.
I asked calculations from AI-robot assistant in chemistry. It is good at calculations, but don't expect to get right answers
from halogenations or the like ...

 

[loadingST]

I still havent tried the reaction but with good hydrolisis with KOH and then with HCL it shoud give high yield, and im afraid working with h2o2 to dont form any explosive peroxides and upon destilation to dont explode

 

[William D.]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William D.]

In fact, there is no need to use peroxide.