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NEP is a synthetic cathinone, and its subjective effects typically fall somewhere between those of a primarily dopaminergic stimulant (like a-PVP or metha) and those of entactogenic stimulants (like MDMA or mephedrone). NEP primarily acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), enhancing dopamine and norepinephrine availability in the brain. While it may have some serotonergic activity, it is weaker compared to serotonergic-heavy cathinones like mephedrone or MDMA.
NEP is known to produce a sense of euphoria, which is more reminiscent of substances like a-PVP or methamphetamine rather than the "lovey-dovey" feeling typical of MDMA or mephedrone. Users often report a strong boost in energy and focus, characteristic of dopaminergic stimulants. Similar to other cathinones, NEP has a high potential for compulsive redosing, linked to its rewarding dopaminergic activity.
While some users may feel a slight enhancement in sociability or empathy, it's usually not as profound or emotional as with MDMA or mephedrone. This aligns with NEP’s weaker serotonergic action. The physical sensations (e.g., body warmth or tingling) are present but tend to be more stimulant-like than the rushes or waves of bliss associated with entactogens.
As with many cathinones, NEP may cause vasoconstriction, increased heart rate, and sweating, similar to other potent stimulants. Due to its dopaminergic dominance, higher doses can produce anxiety, restlessness, or paranoia, aligning it more with drugs like a-PVP than MDMA.
