4-MMC (mephedrone) synthesis. Complete video tutorial.

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Both work and both are good.
 

round2

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Hi Marvin
Great video and I have successfully synthesized 4mmc using this synthesis, thanks. Worked beautifully when acidified with hcl35 but using hbr48 turned out to be a disaster..is hbr not interchangeable with hcl for acidification of 4mmc in benzene?
 

round2

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Btw I used DMSO instead of nmp for the second round
 
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C10H11BrO + CH5N → C11H15NO + HBr
As can be seen from the equation, one molecule of 2-bromo-4-methylpropiophenone produces one molecule of mephedrone.
C10H11BrO : 227.0977 g/mol
C11H15NO : 177.2429 g/mol
227.0977/177.2429=1.28127953
The coefficient is 1.28127953
This means that from 100g of 2-bromo-4-propiophenone, you will get 78.0469818g of mephedrone base.

The mass of mephedrone hydrochloride will increase by 1.19 g/cm3 and the coefficient will be 1.27273446
C11H15NO+HCl=177.2429+1.19=178.4329
227.0977/178.4329=1.27273446

100g(C10H11BrO)/1.27273446=78.5709849g(C11H15NO)
The theoretical yield of the reaction of 2-bromo-4-methylpropiophenone was 78.5709849g mephedrone hydrochloride. But it should be considered that it is difficult to achieve the theoretical yield, usually the loss is 20%.
 
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Bazooka90

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I have found a supplier of 2-Bromo-4-Methylpropiophenone liquid but i dont know how to start from this point and how much liquid should i use to make 100g of 4mmc.I need some advices.
 

Nsowonxmd

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To bych. Nedělal. V kapalině. (Voda). Dobrej. Pepřák
 

William D.

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Not qualitatively purified, or little time for the reaction. More details are needed.
 

whitelabel

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Greetings

4mp to 4mmc successfully this way for me but starting 4mp was yellow so bromination done as per process.

Resultant mephedrone was a pasty powder and not crystal like salt as in video. Power was also low even after crystallization. Any thoughts on the pasty powder and low power. Yield was about 120 gms recrystallized from 400 ml 4mp.

Is there any way to purify the 4mp we get to start with or is that fine?

Would a superior product be possible if 4mp is brominated using NBs and PTSA, purified with a solvent nd then make the nmp synthesis from that 2b4m?

Thanks in advance. Tc
 

Tsigger

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I didn’t add acetone, just MMC freebase in benzene, and I dripped in 30% HCl at pH 5.5. I added the acid slowly. Could acetone be the issue? I forgot, because I usually acidify with DCM+water, so acetone didn’t come to mind. How did you acidify the beauty in the picture? Thank you very much.
 
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goatlabs666

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Thanks bro
 

goatlabs666

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One question, im new in chemical. What Is NMP? Im sorry for the stupid question…
 

loadingST

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N-methyl-pyrrolidine and its toxic to the fertility be awere.
 

NieDoswiadczony

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  • WODA BROMOWA
  • Nazwa odczynnika (ang.): Bromine water
  • Gatunek: czysty
  • Wzór sumaryczny: Br2
  • Masa molowa [g/mol]: 159,82
  • Pojemność [ml]: 1000
  • Numer WE: 231-778-1
  • Numer CAS: 7726-95-6
  • Zawartość [%]: 4is it suitable for synthesis
 

had3s

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Awesome tutorial!

I have question. Can be this tutorial used for 3-CMC or 3-MMC?
 

Amorking

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had3s

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I'm using 2-bromo-4-methylpropiophenone for 4-MMC. What to use for 3-MMC?
 

dodobird

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@Marvin "Popcorn" Sutton can we scale this up using a 50litre batch reactor and drop the bromine Benzene mix from the reactors dropping funnel without any issues?
Bromine mix in an enclosed dropping funnel is a litle scary
 

santi

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dodobird

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Your reply is not clear please explain. What you said exactly
 

santi

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