SGT-263 (CUMYL-5F-P7AICA)

[William D.]

Reaction scheme:

Synthesis:
1. A solution of 1H-pyrrolo[2, 3-b]pyridine-3-carboxylic acid (0.49 g, 3 mmol), oxalyl chloride (0.6 mL, 7.2 mmol), and DMF (1 mL) in dichloromethane (20 mL) was stirred for 20 min.
2. The mixture was evaporated and then redissolved in methanol (20 mL) and stirred for 40 min.
3. The mixture was evaporated and then extracted with ethyl acetate.
4. The organic phase was washed with saturated sodium bicarbonate solution and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.36 g, 68%).
5. A solution of Step 4 (0.36 g, 2 mmol), potassium t-butoxide (0.27 g, 2.4 mmol), and 1-bromo-5-fluoropentane (1.6 g,9.5 mmol) in THF (20 mL) was stirred for 24 h.
6. The mixture was extracted with ethyl acetate.
7. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo.
8. The residue was purified by silica gel chromatography with stepwise gradient elution of n-hexane/ethyl acetate (3:1–2:1–1:1, v/v) to yield the white solid (0.35 g, 65%).
9. A solution of step 8 (0.35 g, 1.3 mmol) and 6 mol/L sodium hydroxide solution (10 mL) in methanol/THF (2:1,v/v, 15 mL) was stirred for 1.5 days.
10. The mixture was evaporated, added to water, and then washed with ethyl acetate.
11. A solution of 1 mol/L hydrochloric acid was added to the aqueous phase, and the mixture was extracted with ethyl acetate.
12. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.39 g, quant.)
13. A solution of step 12 (0.39 g, 1.3 mmol), oxalyl chloride (3 mmol), and DMF (1 mL) in dichloromethane (12 mL) was stirred for 10 min.
14. The mixture was evaporated and then redissolved in dichloromethane (10 mL).
15. Cumylamine (2 mmol) and triethylamine (0.5 mL) were added to the solution and stirred for 15 h.
16. The mixture was evaporated and then extracted with ethyl acetate.
17. The organic phase was washed with 0.1 mol/L hydrochloric acid solution, saturated sodium bicarbonate solution and brine, and then dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.37 g, 77%).​

 

[onionexpress]

Najlepša hvala! Ali mi lahko navedete razmerja za 1 kg končnega izdelka ?

 

[MuricanSpirit]

Kot "osnovno pravilo" preprosto vse pomnožite s 370x (1000g/0,37g = 370 razmerje).

Seveda sem prepričan, da nekatera topila omogočajo večjo gostoto zmesi, npr. ne potrebujete 370x več etil acetata, vendar hitro opazite, kdaj je raztopina prenasičena, vendar imejte v mislih, da večja toplota omogoča večjo nasičenost (ne vem, zakaj).

 

[onionexpress]

Hvala za to, cenim to. Vendar sem novinec in potrebujem posebne informacije, da se izognem napakam.

 

[onionexpress]

Ali lahko kdo naloži videoposnetek z učnim gradivom? Sem novinec in ne želim vedeti vsakega koraka (vključno s potrebno opremo). Zahvaljujem se vam za to.

 

[William D.]

v PM

 

[00000000]

can u send me to pls hvala.

 

[BackstagePanther]

Pozdravljeni, ali je to analog 5F-UMYL-PEGACLONE (5F-SGT-151) ?
Ali nameravate naložiti tudi njegovo sintezo? To bi bilo več kot zanimivo.
Zahvaljujem se vam za vaše izjemno delo.

 

[G.Patton]

Ima različno ogljikovo ogrodje

 

[BackstagePanther]

Oh, pravkar sem ugotovil, da osnova 5F-SGT-151 vsebuje in cel tretji benzenov obroč. Naložitev nomenklature.
Zanimalo me je, ali bi lahko 5F-SGT-151 izdelali in namesto 1-bromo-5-fluoropentana uporabili kot rep,
bi lahko uporabili 1-bromo-6-fluoroheksan. Ali bi nam to dalo še večjo afiniteto do receptorjev / učinke?

 

[G.Patton]

Glede na te podatke bi rekel da, vendar je to le hipoteza.

 

[Lordseeds]

 

[Lordseeds]

Da, mislim, da bo to dovolj. Imam še eno vprašanje. Kateri so najmočnejši kanabinoidi?

 

[William D.]

adb-čminaca in nekatere klasične vrste noidov.

 

[king of synthesis]

Pozdravljeni,
Ali je piridin alternativa kalijevemu tercbutoksidu v tej reakciji?

 

[soebunies]

ni

 

[jejekororun]

I am interested in the synthesis of 5F-adb is there a simple reliable recipe?