Jednoduchá syntéza metylónu (bk-MDMA)

[karamelosanto]

HI, Ďakujem za zdieľanie tejto syntézy, myslím, že je veľmi jasná.
Som z Južnej Ameriky a tu je trochu ťažké nájsť DCM. Môžem sa však pokúsiť ho nejakým spôsobom nájsť. Možno ho kúpiť z Číny.
Chcem sa spýtať. Mohli by ste uviesť všetky regenty v zozname s množstvami, aby bolo trochu ľahšie pochopiť, čo musím kúpiť. Ak je to možné, aj s odhadovanou cenou.
Vďaka!!!

 

[Professor11]

Pode me mandar uma mensagem? Sou da América do Sul também, estou iniciando na produção de Metilona.

 

[Marvin "Popcorn" Sutton]

V tabuľke je uvedená hustota 40 % metylamínu 0,89 g/ cm3, preto sa v 20 ml získa 7,18 g čistého plynného metylamínu.
Porovnajme molekulové hmotnosti metylamínu a jeho hydrochloridu:
M (CH3NH2)HCl = 67,518 g/mol
M CH3NH2 = 31,057 g/mol.
Pomer = 2,174
Ak použijete pomery zo syntézy, budete potrebovať 15,6 g metylamínhydrochloridu na nahradenie 20 ml 40 % roztoku metylamínu.
Metylamínhydrochlorid je potrebné vopred rozpustiť v pomere 1 g na 2,5 ml vody (15,6 g a 39 ml).
Pripravte roztok hydroxidu sodného (NaOH) z 18 g a 54 ml vody, nechajte ho vychladnúť a nalejte ho do banky s roztokom 2-bróm-3,4-metyléndioxypropiofenónu. Potom pridajte roztok metylamínhydrochloridu. Potom pokračujte podľa pokynov.

 

[arundo]

Hello, I'm doing the math, and I see that the molar ratio of NaOH isn't equivalent with methylamine HCl. It doubles. It's for some reason?

 

[antrax]

Chcem sa pokúsiť o chemickú syntézu bk-MDMA Všetky potrebné chemikálie som už kúpil, začnem priamo od prekurzora 2-Bromo-3',4'-(metyléndioxy)propiofenón (číslo CAS: 52190-28-0), keďže som ho už kúpil od čínskeho dodávateľa chemikálií a zaplatil som 280 dolárov za 1 kg vrátane dopravy, od 25 kg zaplatím 200 dolárov za každý kg.
kg vrátane dopravy.

Kúpil som 40 % vodný roztok metylamínu od poľského dodávateľa, hoci nebolo ľahké ho nájsť, a ostatné chemické výrobky sú ľahko dostupné na vnútroštátnom trhu, okrem 36 % kyseliny chlorovodíkovej som našiel len 35-38 % analytickú kyselinu chlorovodíkovú, ktorú som kúpil, síran horečnatý som nevedel, ktorý mám kúpiť, takže som kúpil bezvodý.

Ácido clorhídrico 35-38% AGR Reag.Ph.Eur.

HCl

www.letslab.com

Magnesio Sulfato anhidro GLR

MgSO4

www.letslab.com

Budem postupovať podľa nasledujúcej chemickej syntézy bk-MDMA, pretože sa mi zdá jednoduchšia ako tá, ktorú ste zdieľali, ale možno sa mýlim, bol by som rád, keby ste mi vyjadrili svoj názor.

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/bk-mdma-synthesis-easy-and-fast-method.6423/

Ďakujem!!

 

[Eddybeaumont]

hello mate, can you give me an address to buy cas 52190-28-0 please?

 

[Osmosis Vanderwaal]

Someone asked me the other day about using sesamol to get MD-P1P, and it looked possible. Any opinion on that?

 

[William D.]

Doubtful route. If someone says how to do it simple, we will be glad.

 

[Wan Jack]

In a reaction kettle equipped with a condensing reflux, stirring, dropping and heating device, 111.3 g of catechol, 500 ml of dichloroethane and 166 g of ZnCl2 were added, stirred, cooled to 0-5°C, and 140 g of propionyl chloride was slowly added dropwise for about 2 hours, then the temperature was raised to 20°C and the reaction was continued for 15 hours. After the reaction was completed, water was added for dilution, and the organic phase was separated. The organic phase was sequentially acid-washed and washed with water, dried with sodium sulfate, desolventized, and the residue was recrystallized from ethanol to obtain 144 g of solid 3,4-dihydroxypropiophenone with a melting point of 145-146°C, a content of 98%, and a yield of 85%.

 

[William D.]

Yes, this method is more understandable. But I heard that you can use iodine as a Lewis acid catalyst. For more moderate conditions. I did not have time to check it, but I think that there is need study. Because the chinese intermediate of this substance have is of very poor quality, I think they have problems with the synthesis.

 

[Wan Jack]

Please refer to the next step( Patent: US1964973 , 1932)

 

[Wan Jack]

Sesamol Obtain MD-P1P No relevant information found

 

[Wan Jack]

Preparation of 3,4-methylenedioxypropiophenone
Methanesulfonic acid (MSA, 288 g) and propionic anhydride (156 g) were charged into a 1-liter reaction flask. The mixture was cooled to 0°C and 122 g of 3,4-methylenedioxybenzene (MDB) was added under stirring. The reaction mass was maintained at 0°C to 5°C for 4 hours under stirring. After the completion of the reaction, the reaction mass was diluted with water and the 3,4-methylenedioxypropiophenone product and unreacted MDB were extracted using toluene. The toluene layer was distilled to recover 13 g of unreacted MDB and obtain 142 g of 3',4'-methylenedioxypropiophenone (GC purity > 98%, yield 131% w/w based on consumed MDB). The water layer was distilled to recover 273 g of MSA (purity > 98%), which could be reused in subsequent batches.