Mephedrone synthesis (4-MMC) in NMP solvent. Large scale.

[bubuka]

I would like to make MMC in NMP. The problem is that I don't have pH paper. How problematic is it if I over-acidify at the end? Or could you tell me how much 30% hydrochloric acid I should add at the end when using 100g of 2b4m? I'm acidifying in DCM+water.

 

[WillD]

If you do not have enough experience, you need to use indicators to obtain the maximum yield. If this is not possible, we can calculate you the amount of acid minimal, which you can add to get the product.

 

[TheVacuumGuy]

If you buy electric, do yourself a favor by spending extra to get a glas probe. Otherwise it will dissolve (yes, been there)

 

[c01db100d_india_mephedron]

can we replace
hydrochloric acid to hydrobromic 48%
if its possible how much product yield and how much quantity we want

 

[WillD]

Yes, you can use this replacement. The weight of the product under the same conditions will be slightly more.

 

[c01db100d_india_mephedron]

Thank you for your valuable advice
@Dr. MMX @WillD @G.Patton

 

[c01db100d_india_mephedron]

HCL (36%)
Cas no. Plz

 

[Hanna520]

Why to use Benzene and NMP. Use Ethyl Acetate instead. Much safer. Change the mono methyl amine aqua for alcohol based.
After adding water. Separate layers. Take the “oil” layer and distill the EA off. Fatter this step. Cool down the base oil for 1 hour in freeze -19. The unreacted side products will come. Filter the solution and put the base in AC and with HCL37% add pH to 5.5.

Don’t use a flame for heating. Use a bath instead. This setup will give you good results. )

 

[momogf]

Good way i made my self 2bromo4metylenopropiophenone

 

[dnBQByvHb8Zkawbjpx]

This was discussed in the main chat few days ago. The general recommendation was to distill the EA off at 55 °C in vacuum (/negative pressure) for improved yield. Is this what you meant, or did you mean to distill at normal pressure at 77 °C (boiling temp of EA)?

This is the first time I read about this and I shall try this.

I will start a thread about maximizing 4-MMC yield and invite you to share your knowledge. You seem to know a lot about this.

 

[WillD]

Yes, the ethyl acetate method is good if you have methylamine alc. soln. It solves many problems.

 

[Germanium]

Is it possible to bubbling hydrogen chloride gas instead of adding hydrochloric acid during the crystallization stage?

 

[dnBQByvHb8Zkawbjpx]

Yes this is a good alternative to using hydrochloric acid, as long as you meant to say "acidification" instead of "crystallization". No acid is added during the crystallization stage.

 

[Germanium]

Thank you so much!