4-MMC (mephedrone) synthesis. Complete video tutorial.

[Chenzen]

If you have good synthesis cost 1kg 4mmc crystal can be 300€

 

[G.Patton]

Yes, I did it personally. Usually, there are not a lot of side-products. The synthesis is very easy and it is hard to spoil a final product of 4-MMC. Also, crystallization will purify it properly to make a large crystals.

 

[WundaBearz41]

So add the methylamine HCL to the 2-bromo mix. Then add in: 1:5 ratio of NaOH in water. For this synth 200 ml is needed of Methylamine Aqueous solution, would this ratio work?

Pour in:
75ml water add 67 gr Methylamine mixed
Slowly pour in afterwards:
20gr of NaOH to 100ml water mixed, Slowly pour in

 

[Chemix-Express]

When adding NMP, keep an eye on the temperature not to exceed 55 or 60 degrees? (Which option chemically speaking is more suitable giving a cleaner product / higher yield?)

Any examples of what you can replace Benzene with? Toulene? DCM?

 

[Chemix-Express]

Using 200g BK4 after reaching 40 degrees C, adding m40 in such a way as not to exceed 60 degrees C takes about 25 minutes.

When adding m40, should the mixture be cooled to add the entire portion fairly quickly?

 

[G.Patton]

You have to add methylamine solution in portions in order to keep temperature below 55-60 *C.

 

[Czeczeczecze]

Hi if I want to make 3 cmc instead of 4mmc with this synthesis which reactants i must to change? Can i use this synthesis with x2 scale?

 

[G.Patton]

Hello, 4'-methylpropiophenone to 3'-chloropropiophenone and yes, correct.

 

[WhalterWhite]

3cmc is not methylopropiphenone...This is 3mmc.
3cmc- 2b3chloro

 

[G.Patton]

You are right, from 3'-chloropropiophenone

 

[Mr.Blanks00]

hello friends, do you feel burning on your tongue by using toluene as a final product and feel glassy, sore eyes or not friends.

 

[danim18]

guys what does it mean organic synthesis ?

 

[Mr.Blanks00]

Sir, I want to ask, can mephedrone be made in sulfate version, and can mephedrone sulfate be as stable as mef hcl.

 

[G.Patton]

It is extremely hygroscopic and hard to crystallize. Forget about this idea.

 

[G.Patton]

Organic Synthesis

For those who think it's easier to annoy you than to Google 'Organic synthesis' themselves.

letmegooglethat.com

 

[tajira]

[question]
I already done barely - successful synthesis.
basic info:
I started from 50g of 2-bromo-4-methylpropiophenon (so I should get minimum around 25 gram of final 4MMC product)
everything came slight to step when final product starts form
My problem is:
after acidification (ph is goods should be) I let freebase to cool in freezer, after more than 10hours my yield was around 12g of bone-dry product,
but in this was still a lot of product so I add acetone to it and let it cool again then I got extra 5 more grams of it.

Can anybody tell me what's problem?
my conception is
"there is too less solvent at the and and Mephedrone have too small space to form" but I dont know is it true or not.
can anybody help me found a solution?
Best regards and thanks.

 

[G.Patton]

It isn't correct. You can evaporate filtrate after first crystallization to 1/2 and freeze it. Then you'll get less pure mephedrone, which can be recrystallized.

 

[hustla]

it's the opposite, you should evaporate the solvent, not add more

adding more solvent will make more space for your product to be dissolved in, evaporating the solvent makes "less space"

 

[StarWars]

Bro dont say bulshit

 

[G.Patton]

Actually he is right. The less substance concentration, the harder crystallization and more losses. More substance be dissolved in solvent.