Ephedrine extraction from pills methods

[G.Patton]

Yes, you have to do it firstly. I don't know where is your problem. I can't guess and answer you without your detailed procedure explanation.
Okay, google: vm&p naphtha composition
then, you have to chose same one or similar. I think Kerosine is best one. Do you see that you need just use google and ask it? It really works well for simple questions like yours.

 

[JustAnother0rganic]

may i take it for light petroleum ether (25C to 80C) ? instead of heavy.

 

[G.Patton]

Hi
I guess so

 

[JustAnother0rganic]

Rgr That !
Never know the corresponding equivalent about naphta when its said "no replacement"
naphta= light petroleum ether
i ll tell you if i am still valid after my chemistry performance o_x'

 

[ice]

Hello, Patton, in method two, can acetone be used instead of methyl ethyl ketone? Can xylene be replaced with toluene? Can you show me a picture of the pseudoephedrine hydrochloride extracted from the pills? At one point I had an extract that was like fiberglass, but I'm not sure that was it.

 

[zaners]

Will the pseudo hcl crystals form in the filter when you in this step?............. ,.............. .......11) Using a clean funnel and filter, paper filter off the pseudo HCl while the solution is hot.
12) Rinse the pseudo HCl with a generous amount of MEK while in the funnel.

13) Remove filter and filter cake from funnel and allow to dry completely. (no more MEK smell)

 

[bobbrown1488]

after 11 do i place in freezer before 12 ? i think i was confused here because no gas

 

[zaners]

I started method 2 and the pills aren't dissolving..I took coating off to..should I grind

 

[zaners]

What can I do if some of my activated charcoal made it through my filtering?? Redissolve and filter again?

 

[zaners]

In the first method it says the left over napatha will have pseudoephedrine freebase in it so add water and "titrate"how do you titrate?

 

[bananabebop]

I am trying with ephedrine sulfate.
Pills have binders in them that hold onto ephedrine even when doing A/B extraction.
PEG
Polyvinyl Alcohol
Dibasic Calcium Phosphate Dihydrate

Pills has mass of 50mg, and has 25mg ephedrine sulfate content.
Amount from water extraction expected: 20mg-25mg

Get 5mg ephedrine sulfate, after filter of bulk material, and evaporation of water.
Confirm with lieberman reagent, turns yellow/orange.
Bulk material after extraction is 42mg - indicates unextracted ephedrine sulfate remains in bulk material.

I have tried with A/B extraction, also.
From water solution with dissolved pill, add NaOH to basify to ph12.5+. Shake 3x, let sit.
Add nonpolar solvent petroleum ether, to extract ephedrine freebase. Shake 3x, let sit.
Three extractions done with petroleum ether.
Let petroleum ether evaporate.
Non ephedrine freebase present. Lieberman reagent turns brown.
Is it that freebase ephedrine reacts differently with lieberman reagent?

What is happening?

 

[zaners]

Is there a easy way to do it if you not in a hurry from the pills

 

[bobbrown1488]

is method 1 for ephedrine an #2 for Pseudoephedrine ?
8mg ephedrine hcl
Additional Ingredients: Microcrystalline cellulose, magnesium stearate, calcium phosphate, silicon dioxide.
what method would you recommend ?
thank you

 

[nkd23]

Is this method also useful for Morphin pills?


Compensan 200mg (Morphin Hcl)

morphine hydrochloride trihydrate.
1 film-coated tablet contains 200 mg
Morphine hydrochloride trihydrate equivalent to 151.9 mg morphine.
- the other components are:
Tablet core:
Lactose monohydrate, polyacrylate dispersion 30%, Eudragit L, ammonium methacrylate
Copolymer type B, hypromellose 4000, magnesium stearate
Film coating:
Macrogol 6000, hypromellose 5, polyacrylate dispersion 30%, titanium dioxide (E 171),
Iron oxide red (E 172)

 

[Duart77]

In the first method, can I replace VM&P naphtha with mineral spirits?

 

[Nikolas]

Can I use petroleum ether instead of naphtha?

 

[B.d.p.n.e]

İ have 2 questions

Can I use this product instead of naphtha?

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10 of the second method. I didn't understand the stage

Won't ephedrine be soluble in boiling solvent anyway? How do I filter out dissolved ephedrine? Or do we just boil alcohol and other things and let xylene stay there, and ephedrine doesn't dissolve in xylene?

 

[B.d.p.n.e]

@G.Patton Sorry for the inconvenience, but I really didn't understand this, and this method is important to me, I would be glad if you could help

 

[G.Patton]

Hello, I guess so, but there is no composition explanation. Some other solvents may be there in addition with original one.
Ephedrine will be left on the filter paper. I guess it's clear from the following step.

 

[B.d.p.n.e]

So ephedrine will not be soluble in the hot solution and will remain in the filter paper, is it?

 

[G.Patton]

Yes

 

[B.d.p.n.e]

Thanks

 

[d3vil4u]

Hello,
with the method 2 i got 4.32g ,but the maximum yield should be 1.4 g. What is this and how can i clean it ?
I used Olygrip pills wich have 60mg per pill and 12 pills per box and i used 2 boxes.
should i try to recrystallize it ?how can i do it without DCM?