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In terms of this synth, given bits of the product are turning red, would it not make sense to instead of going straight to adding a KOH solution to it, add it to a 5-7% acetic acid solution - protonate the DMT, then defat it with, well whatever works, possibly xylene (hexane didn’t work for me) and then sep that off and THEN go to base and extract with the DCM?
Then do a re-x from heptane? Then into the freezer eventually given I can’t do negative pressure for long as it’s loud!
The oil I end up with AFTER the re-x is really annoying and the majority of the product.
Either the above - OR I guess I could re-x THAT with something else like alcohol? I dunno, it just seems like not a lot is done in the ‘workup’ to get rid of any of the shit that is turning my DMT red over days and taking fucking ages to solidify a goo that doesn’t want to ‘set’ - there has to be an easier way lol
Now I’m not an expert chemist but I do some simple principles lol
I also have a lot of tryptamine to either burn or succeed but no more larger experiments until I can settle it small scale now. It’s pointless…I need to work out exactly how much heptane people are saying when they say LOTS. I’m using probably 20-40x the amount of heptane as there is oil to re-x from.
Also, I’m unclear, do I heat the oil up with the heptane from cold or do I throw the boiling heptane onto the oil and then start heating and stirring in a seperate beaker?
Then do a re-x from heptane? Then into the freezer eventually given I can’t do negative pressure for long as it’s loud!
The oil I end up with AFTER the re-x is really annoying and the majority of the product.
Either the above - OR I guess I could re-x THAT with something else like alcohol? I dunno, it just seems like not a lot is done in the ‘workup’ to get rid of any of the shit that is turning my DMT red over days and taking fucking ages to solidify a goo that doesn’t want to ‘set’ - there has to be an easier way lol
Now I’m not an expert chemist but I do some simple principles lol
I also have a lot of tryptamine to either burn or succeed but no more larger experiments until I can settle it small scale now. It’s pointless…I need to work out exactly how much heptane people are saying when they say LOTS. I’m using probably 20-40x the amount of heptane as there is oil to re-x from.
Also, I’m unclear, do I heat the oil up with the heptane from cold or do I throw the boiling heptane onto the oil and then start heating and stirring in a seperate beaker?
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What defat? There's no fat, as it's not a plant extraction. Or you doing the reaction in a dirty saucepan with some cooking oil left?
You say it's getting red, that's normal if you leave it in open air.
You extract with DCM then evap the DCM as much as possible. Then add to that same flask quite a bit of naphta/heptane, everything done with stirring, both DCM evap and now adding you recrystallization solvent.
Now, there's some goo in your hot naphta that doesn't want to dissolve, you either filter that shit or carefully pour the naphta out, so that you don't pour this goo together with the liquid.
After you have extracted this stuff and put it into a glass, then freeze precipitated all the substance, and there's some yellow or white oil at the bottom, you can use a hack. Pour out the used naphta into a clean bottle. Take your dish, without a naphta now, and let it dry a little bit. Scrape it and move everything into a new beaker, heat that beaker while stirring until you start to smell of dmt, most of the leftover solvent will evaporate in that little time. This hot DMT liquid you can pour into one more glass container, as it cools down, it willl turn into white to slightly yellow wax, you can scrape it after it cools and make a fine powder out of it with a sharp blade.
Pack the powder into an air-tight bag, so it doesn't turn red.
You say it's getting red, that's normal if you leave it in open air.
You extract with DCM then evap the DCM as much as possible. Then add to that same flask quite a bit of naphta/heptane, everything done with stirring, both DCM evap and now adding you recrystallization solvent.
Now, there's some goo in your hot naphta that doesn't want to dissolve, you either filter that shit or carefully pour the naphta out, so that you don't pour this goo together with the liquid.
After you have extracted this stuff and put it into a glass, then freeze precipitated all the substance, and there's some yellow or white oil at the bottom, you can use a hack. Pour out the used naphta into a clean bottle. Take your dish, without a naphta now, and let it dry a little bit. Scrape it and move everything into a new beaker, heat that beaker while stirring until you start to smell of dmt, most of the leftover solvent will evaporate in that little time. This hot DMT liquid you can pour into one more glass container, as it cools down, it willl turn into white to slightly yellow wax, you can scrape it after it cools and make a fine powder out of it with a sharp blade.
Pack the powder into an air-tight bag, so it doesn't turn red.
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Okay yeah that all makes sense.
I mean I have heard of them talking about defatting in the workup from this reaction - I did think it was odd but at the same time Hamilton generally knows what he’s talking about - as do his guests.
It’s strange - maybe he (the self taught chemist that was being interviewed) didn’t mean defat and got the term wrong (it was a self taught chemist but iv looked up the syntheses he’s been speaking of and he was no bullshitter)
Either way, that is a pretty genius hack I would not have thought of! So is this clear oil I am left with at the bottom simply DMT with traces of heptane I can’t get out of it?
Also, I realised - why the heck am I doing this in such a massively oversized RB with loads of space left for air?…not ideal I’m realising.
Also I DID NOT realise it had to be constantly stirred pretty much from the point you extract the yellow ‘goo’ with DCM - that may well have affected things.
And just 1 more thing - I’m really glad you said naptha/heptane as heptane is quite expensive in this country (don’t know if it’s coz I could only find n-heptane or if that makes no difference) but iv loads of fresh, dried naptha. I do understand they are not the same thing - do not mistake me, however, its comforting to know that at a push I can still use that.
Okay so a lot to work on! Thanks for the tips, seriously.
The MiPT synthesis was a failure - well, better put, the workup was a failure but I stupidly attempted it late at night whilst I wasn’t really thinking clearly but at the same time I knew I had a plumber coming today haha
I guess let’s stick to one thing at a time!
Does ANYONE ELSE face these sorts of STUPID scenario’s? It’s probably just me and my bad planning and fucked up life management….
Don’t get me wrong, I would NEVER let ANYONE see any piece of glassware or anything I can’t put with my painting stuff, it’s just the constant getting out, putting away, getting out etc etc - I’m moving soonish to a bigger place so may even have space for a perma-lab!
Anyway just a glimpse into the silliness of my life! This is why I need DMT and other psychedelics because every other time iv taken them off the table with the benzodiazepines and opiates already being off the table, it just doesn’t work for me.
I have been in some of the most savage withdrawals coming off these benzos and the part of that journey where I used psychedelics vs the part where I didn’t is drastically different. It’s more about a sense of it feels like it resets my brain somehow - particularly longer trips, they seem to have a much longer afterglow but there is something about DMT and the worlds it takes me to…
I probably have like 450g of tryptamine left and I’ll be working on a way smaller scale until I can figure it out better…so plenty of time for improvement! lol
I actually wanted to ask you guys something about when you consume n,n-DMT. Someone said to me oh I don’t find smoking it that great and described sitting with his eyes open.
Whenever I smoke DMT the bad trips have been when iv forgotten to close my eyes and I just can’t see or I think I see my hands like turning into roots and it’s deeply unsettling but I find as soon as I shut my eyes, it’s far less confusing and scary - for want of a better word. Just wondered on y’all’s experiences!
I mean I have heard of them talking about defatting in the workup from this reaction - I did think it was odd but at the same time Hamilton generally knows what he’s talking about - as do his guests.
It’s strange - maybe he (the self taught chemist that was being interviewed) didn’t mean defat and got the term wrong (it was a self taught chemist but iv looked up the syntheses he’s been speaking of and he was no bullshitter)
Either way, that is a pretty genius hack I would not have thought of! So is this clear oil I am left with at the bottom simply DMT with traces of heptane I can’t get out of it?
Also, I realised - why the heck am I doing this in such a massively oversized RB with loads of space left for air?…not ideal I’m realising.
Also I DID NOT realise it had to be constantly stirred pretty much from the point you extract the yellow ‘goo’ with DCM - that may well have affected things.
And just 1 more thing - I’m really glad you said naptha/heptane as heptane is quite expensive in this country (don’t know if it’s coz I could only find n-heptane or if that makes no difference) but iv loads of fresh, dried naptha. I do understand they are not the same thing - do not mistake me, however, its comforting to know that at a push I can still use that.
Okay so a lot to work on! Thanks for the tips, seriously.
The MiPT synthesis was a failure - well, better put, the workup was a failure but I stupidly attempted it late at night whilst I wasn’t really thinking clearly but at the same time I knew I had a plumber coming today haha
I guess let’s stick to one thing at a time!
Does ANYONE ELSE face these sorts of STUPID scenario’s? It’s probably just me and my bad planning and fucked up life management….
Don’t get me wrong, I would NEVER let ANYONE see any piece of glassware or anything I can’t put with my painting stuff, it’s just the constant getting out, putting away, getting out etc etc - I’m moving soonish to a bigger place so may even have space for a perma-lab!
Anyway just a glimpse into the silliness of my life! This is why I need DMT and other psychedelics because every other time iv taken them off the table with the benzodiazepines and opiates already being off the table, it just doesn’t work for me.
I have been in some of the most savage withdrawals coming off these benzos and the part of that journey where I used psychedelics vs the part where I didn’t is drastically different. It’s more about a sense of it feels like it resets my brain somehow - particularly longer trips, they seem to have a much longer afterglow but there is something about DMT and the worlds it takes me to…
I probably have like 450g of tryptamine left and I’ll be working on a way smaller scale until I can figure it out better…so plenty of time for improvement! lol
I actually wanted to ask you guys something about when you consume n,n-DMT. Someone said to me oh I don’t find smoking it that great and described sitting with his eyes open.
Whenever I smoke DMT the bad trips have been when iv forgotten to close my eyes and I just can’t see or I think I see my hands like turning into roots and it’s deeply unsettling but I find as soon as I shut my eyes, it’s far less confusing and scary - for want of a better word. Just wondered on y’all’s experiences!
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I just realised I should have said I don’t know what DMT smells like ha
Actually that was something I noticed first about tryptamine - it’s similar plasticky smell.
Does 5-meo-t or 5-meo-DMT smell and taste like shit too? Iv smoked 5-MEO-DMT back when my first ever RC vendor (who was basically just selling shulgins products) from Canada but that was probably like 2005 or something? I can’t really remember it - I don’t remember it being mad visual like DMT that’s for 100% certainty. This was before I knew you could just extract it. lol
Actually that was something I noticed first about tryptamine - it’s similar plasticky smell.
Does 5-meo-t or 5-meo-DMT smell and taste like shit too? Iv smoked 5-MEO-DMT back when my first ever RC vendor (who was basically just selling shulgins products) from Canada but that was probably like 2005 or something? I can’t really remember it - I don’t remember it being mad visual like DMT that’s for 100% certainty. This was before I knew you could just extract it. lol