Synthesis of P2P by oxidation of alpha-methylstyrene with Oxone (Potassium Peroxomonosulfate) (1kg scale)

WillD

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Reaction scheme:
6RfIzHmQtn


Synthesis:
1. 25 liters of acetonitrile and 5 liters of water were added into the 200 L reactor.
2.1000 g a-methylstyrene, 5202 g potassium peroxymonosulfate and 127 g sodium iodide were added to the reactor.
2. The reaction mixture was stirred for 24 h at room temperature.
3. After this time, the reaction mixture was diluted with 85 liters of water and extracted with 30 liters DCM.
4. Water layer discarded, DCM extract was removed to afford a yellow oil.
5. Yield of phenylacetone, about 1000 g.
 
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hardik696

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Sir can you riteup this prosess in smoll scale?
 

The-Hive

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Just half everything and go from there Trial and error
 

WillD

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No problem. Do you have reagents? We can make synthesis
 
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hardik696

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Sir not yet but i buy.
 

WillD

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There is a lot of deception on this site, when it comes to specific chemistry. But Oxone - this product is for swimming pools, it is sold in the appropriate stores. AMS and NaI basically available too. Acetonitrile can be replaced in some cases. What country are you in? You can write a PM for more synthesis details.
 
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Jamroz

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Can i change oxone other reagent ? Because is to hard to buy on big scale in my country
 

WillD

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Potassium peroxymonosulfate or another strong oxidizer
 

hardik696

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don't have reactor.can I use plastic barrel or metal barrel or Steel. Please reply.PM
 

Mr Handy

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Have you try this method. Its correct
 

Ortist

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Thats insane amount of acetonitrile. Can it be substituted?
 

Mr Handy

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Have you try this method. Its correct
 

Andrzej

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1) What is the role of acetonitrile in this reaction? Only solvent?
2) Why need such big amount of acetonitrile in comparsion to other ingridients?
 

situ1984

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Hi,What concentration of acetonitrile should I use?
 

hustlerkid

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Curious what the replacement for acenitrile is for this reaction?
 

The-Hive

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Ethanol believe it or not
 

hustlerkid

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It can be replaced 1:1?
 

jasper

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what is the a-methylstyrene cas? used
 

The-Hive

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UTFSE or Google it
 

Mr Handy

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Have you try this method. It really make phenylacetone
 

jasper

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sir can we use a-methylstyrene as liquid form?
 

The-Hive

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You can buy it £10 1lt
 

jasper

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yes can we use liquid in place of powder form cause it's written gram
 
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