Question Synthesis of ketamine from a nontoxic procedure: a new and efficient route

[hider8028]

Is there any master who can provide a tutorial for this article?

Abstract​

Ketamine [2-(2-chlorophenyl)-2-methylamino-cyclohexan-1-one] has been used in both veterinary and human medicine. In this research, a new and efficient protocol has been developed for the synthesis of ketamine, by using hydroxy ketone intermediate. Synthesis of this drug has been done in five steps. At first, the cyclohexanone was made to react with 2-chlorophenyl magnesium bromide reagent followed by dehydration in the presence of an acidic ionic liquid, 1-methyl-3-[2-(dimethyl-4-sulfobutyl-ammonium) ethane] imidazolium hydrogen sulfate to obtain 1-(2-chlorophenyl)-cyclohexene. The oxidation of the synthesized alkene by potassium permanganate gave corresponding hydroxy ketone intermediate. The imination of this intermediate by methyl amine and finally the rearrangement of the obtained imine at elevated temperature resulted in the synthesis of ketamine. All of the intermediates and the product were characterized by 1H-NMR and IR spectroscopies. No need to use toxic bromine (which is used in most of the reported procedures for the synthesis of ketamine), high reaction yields and use of commercially available and safe materials and no need to use corrosive acids in the dehydration step are some of the advantages of this procedure over the common reported ones for the snthesis of ketamine.

Graphic abstract​

An efficient five-step protocol for the synthesis of ketamine was developed. Cyclohexanone reacted with 2-chlorophenyl magnesium bromide, followed by dehydration with acidic ionic liquid. Oxidation of the alkene gave corresponding hydroxy ketone intermediate. The imination of this intermediate and rearrangement of the obtained imine finally produced ketamine.

 

[WillD]

If you have access to reagents, we can help you do this.

 

[hider8028]

There are not many synthesis routes for KETAMINE on the forum, and the articles are not friendly to novices

 

[wongivan]

Is there any simple method? I'm a novice

 

[wongivan]

Are there any video tutorials?

 

[CremdelaChem]

arylcyclohexylamine syntheses are never simple for novices to attempt. I'd stay away from this synthesis unless you have some considerable synthesis experience & preferably at least a couple semesters worth of theoretical ochem knowledge. I know it is a very desirable drug to make, but you will need to be patient and take the time to practice laboratory techniques and become versed in somewhat advanced techniques to be able to approach a synthesis like this. Vogels textbook of practical organic chemistry downloaded on libgen is a good starting place will get you going with the fundamentals of laboratory wisdom.

 

[HerrHaber]

I can try to help you but there's quite a distance between starting practical chemistry and having success with this one.