Exracting Morphine Sulphate from "Substitol Capsules" and converting it to Morphine Base

Mr_Morphine

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Hi there,

I thought this was common knowledge but since I got asked for a few times here's the how to:

1) Open Capsule which contains little balls of Morphine sulfate covert with a wax-like Substance
2) Put the little balls in hot Water (75°C is perfect)
3) Stir until dissolved

4) Let the Water cool down until there is a hard "Wax" Layer
5) Remove the layer or don't do so depending on your taste
6) Cheers

for converting into smokable Morphine Base:


after step 4: remove the "Wax" layer
5) add ammonia dropwise until pH is about 10-12. You will see the flakes falling out.
optional: cool the solution in the fridge
6) remove water laver
7) let the "Snowflakes" dry and enjoy ;-)

stay safe,
Mr.M.
 

InterestedJimmy

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Can you or someone else provide an in-depth description of cleaning the morphine (base) of this formulation in the most perfect manner to avoid product loss as well as possible? I have been reading many instructions across the various boards about morphine extraction but could not find a step by step procedure. For the experienced (hobby) chemist this might sound trivial. I know these kind of extractions belong to the most basic procedures but I would like to do my best and work as diligent as possible. Therefore I could need some assistance and thereby raise incitement for further projects.

The content inside the Substitol (200mg) capsules contain the following ingredients:

-200 mg morphine sulphate
-hydrated plant oil
-Macrogol 6000
-talcum
-magnesium stearate


My layman approach would be:

Dissolve the content in sufficient hot destilled water and after cooling remove the waxy layer floating on top. The wax should mainly consist of hydrated plant oil. The solution should consist of morphine sulphate + Macrogol 6000 and the magnesium stearate + talcum should float around undissolved. Filtering the solution in order to remove talcum and magnesium stearate should leave a solution of morphine sulphate and Macrogol 6000.

I presume the next step would be basifying the solution to a certain ph value, filtering out the precipitated morphine base and thus leaving behind a solution of Macrogol 6000.

I would like to know the exact figures, equipment and chemicals needed to perform an optimal extraction.
 

Mr_Morphine

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I write a deteiled one as soon as I have time.
 
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