Phenibut & Sleeping pills
Phenibut or β-phenyl-γ-aminobutyric acid is a central nervous system kind of depressant drug that is used to reduce anxiety, improve sleep, and enhance cognitive function.
This substance is frequently utilized for its nootropic and anxiolytic properties. The mechanism of action of Phenibut is attributed to its ability to bind to the GABA-В receptors in the brain, which are responsible for the inhibition of neurotransmission.
This binding leads to an increase in the activity of the GABA system, resulting in a calming effect and a reduction in anxiety. In addition to binding to GABA-B receptors, Phenibut also has a mild effect on GABA-A ionotropic receptors. This substance is known to be a dopamine receptor agonist, although the specific mechanisms of how Phenibut interacts with the dopaminergic system and the precise areas of the brain it affects remain unclear.
Phenibut also acts as an antagonist to beta-phenethylamine, a neuromodulator and anxiogenic substance in the central nervous system. These various effects and interactions of Phenibut make it a complex substance that should be used with caution. It's funny that in some countries Phenibut is sold as a dietary supplement, and in others as a prescription drug.
Sleeping pills, also known as sedative-hypnotics, are medications that are used to treat insomnia or other sleep disorders by inducing sleep. Below is a list of the most common groups of sleeping pills:
Benzodiazepines: Temazepam, Estazolam, Triazolam, Diazepam.
Non-Benzodiazepine Hypnotics: Zolpidem, Eszopiclone, Zaleplon.
Melatonin Receptor Agonists: Ramelteon, Tasimelteon.
Some Antidepressants can also be effective at promoting sleep. For example, Trazodone and Doxepin.
Orexin Receptor Antagonists: Suvorexant.
Barbiturates: Phenobarbital, Pentobarbital.
Antihistamines: Diphenhydramine, Doxylamine.
Others: natural remedies with a sedative effect, such as Valerian roots or Passiflora extract.
The use of Phenibut in combination with other central nervous system depressants, such as all kinds of sleeping pills may result in mutual potentiation of effects and an extended duration of action. The effects of both drugs can be intensified, leading to excessive sedation, muscle relaxation, amnesia, and other adverse effects. At higher doses, there is a risk of experiencing unexpected loss of consciousness, which could result in vomiting and suffocation. The combination can also increase the risk of dangerous levels of respiratory depression, which is a potentially life-threatening condition.
Furthermore, Phenibut can increase the risk of tolerance, dependence, and addiction when taken with sleeping pills. The two drugs can also interact with each other and affect the levels of neurotransmitters such as GABA, which is responsible for regulating sleep and anxiety.
Additionally, this combination has no widespread and confirmed benefits, neither for addressing sleep issues nor for recreational purposes.
All things considered, we recommend avoiding this combination under any conditions.
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