Bromination of 4-methylpropiophenone with CuBr2 (large scale)

WillD

Expert
Joined
Jul 19, 2021
Messages
783
Reaction score
1,073
Points
93
Reaction scheme:
VmX7FJ2Zlz


Synthesis:
1. Added to the flask, 1000 g 4-methylpropiophenone.
2. Poured 6000 ml of acetonitrile or ethyl acetate, and start stirring.
3. While stirring, slowly add the copper(II) bromide 1800 g.
4. Put a reflux condenser on the flask.
5. Heated under reflux for 24 hours.
6. After this time, stop heating and stirring.
7. Distilling the solvent, if needed, to obtain dry bromoketone.
8. We leave away ethyl acetate, if we plan to react in it. Theoretical yield: 1400 g.
 
Last edited by a moderator:

beetlebb

Don't buy from me
New Member
Joined
Jan 7, 2022
Messages
35
Reaction score
28
Points
18
What is the obtain or actual yield on this synthesis?
 

WillD

Expert
Joined
Jul 19, 2021
Messages
783
Reaction score
1,073
Points
93
Approximately 1 kg of finished substance
 

beetlebb

Don't buy from me
New Member
Joined
Jan 7, 2022
Messages
35
Reaction score
28
Points
18

Spindy122

Don't buy from me
New Member
Joined
May 20, 2022
Messages
2
Reaction score
0
Points
1
With ethyl acetate used, this is mostly complete in 1 hour. Complete in 2 hours.
 

Morpheus77

Don't buy from me
New Member
Joined
Apr 8, 2022
Messages
5
Reaction score
0
Points
1
Can this method be used with valerophenone to get a-bromovalerophenone?
 
Top