Question 4-methylpropiophenone synthesis

[NovicechemistEU]

Are my calculations for the synthesis of 4-methylpropiophenone good, ? Can you please take a look, I will make the synthesis tomorrow.

* Toluene:** 500 mmol * 3 = 1500 mmol (This is about 162 g or 162 mL. The density of toluene is about 0.87 g/mL).
* Aluminum Chloride (AlCl₃):** 550 mmol * 3 = 1650 mmol (This is about 220 g.)
* Propionyl Chloride:** 525 mmol * 3 = 1575 mmol (This is about 147 g or 140 mL. The density of propionyl chloride is about 1.05 g/mL).
* Dichloromethane:** 200 mL * 3 = 600 mL (The amount of solvent should also be increased.)
* **Ice Water:** 500 mL * 3 = 1500 mL
**5% NaOH:** 300 mL (3 x 100 mL)
* Water (for washings):** 300 mL (3 x 100 mL)
Remove the decanter at 40 degrees Celsius.
20 mmHg (740 mmHg) 123 degree vacuum distillation

 

[TucoSalamanca.]

this synthesized glass balloon is very polluting, be careful not to pollute yourself

 

[Osmosis Vanderwaal]

I suggest you go back and figure your ingredients more closely. I get 138.21 ml= 1.5m toluene, thats 25g, nearly an ounce, that your off on the first thing. If i went throubh this whole thing and calculated and added all the percentages you are off by, it's obviously a large amount.
Theres something wrong with your vacuum reading also 740mm/mg is only 0.5 psi less than atmosheric at see level. It would lower your boiling point 2 degrees at most and is a waist of time if it were right, but its not.

 

[NovicechemistEU]

Sir, I've changed my mind. I'll synthesize Mr. Willd's synthesis instead.

 

[NovicechemistEU]

Sır, Could you check my calculations as follows.
Propionyl Chloride: 328.5 g ≈ 312.9 mL (at 25°C)
Toluene: 857.56 g ≈ 985.1 mL (at 25°C)
Aluminum Chloride:493 g

Synthesis of 4'-methylpropiophenone from toluene by Friedel-Crafts reaction

 

[Osmosis Vanderwaal]

I get 991ml= 857.56g toluene
347.8815 ml=328.5g prCl
Clearly you're doing something wrong

 

[loadingST]

You need coolinglots of ice and hcl acid to remove alcl3 complex and leave with the ketone, actualy i have tried to calculate which is cheaper to make ,4mp myself or buy it read the difference is araund 60-70$ per kg for all that work and do you plan on soing fractional destilation to isolate isomers 3mp and 4mp

 

[NovicechemistEU]

If you can buy, stay away from producing.
I'm looking for excitement.
You don't want to mess with these chemicals.
I got a 90% yield on the synthesis.

 

[NovicechemistEU]

It's hell to stand in an environment with propionyl chloride

 

[Osmosis Vanderwaal]

If you made this in your house or garage without a seious fume system, itll be like Chornobyl, you wont be able to stay there afterwards

 

[loadingST]

Outdoor is always good option but really working with chemicals and cancirogens acids bases any vapours in hause is like killing yourself slowly throw skin

 

[Precursor-supplier]

It is more convenient to purchase directly from China, I also sell this product,