Alright,
So I am working with phenethylamine’s and have made mescaline and reduced quite a few other nitroalkene’s with great yields.
I would like to make some 2c-e and given that I have 2,5-DMOBA, and I only want to make a small quantity so yield isn’t as important to me as flexibility, could I perform a Grignard ethylation on the 2,5-DMOBA?
I understand that people usually start from the acetophenone but I can only buy precursors in large amounts (well large in terms of what I actually need) and it doesn’t make sense to buy a load of that and start from that.
I would react 2,5-DMOBA with EtMgBr (probably as a premade solution) in an argon atmosphere, in an ice bath…
Is this something that is going to work? I’m a little worried about purification but figured the boiling point shouldn’t be radically different to the starting aldehyde - a little higher of course.
I dunno; 2c-e is something I REALLY want to make, iv not consumed any for YEARS (since 2000’s RC times) and it’s probably my favourite psychedelic - CERTAINLY my favourite phenethylamine so far…
I am obviously learning and I figured adding an extra step at the beginning of the process would make sense…
I did look into friedl-crafts alkylation but poo poo’d the idea. I’m sort of hoping this idea is AS MUCH of a poo poo.
As I say, I’m happy to get crap yields as I don’t need much anyway.
I also realised that it’s only when you haloginate at the 4 position, that the NaBH4 / copper catalysed reduction kicks it off - handy for me here…hopefully
If I AM being a mad amateur like a lot of my old posts on here are (which have all been bought up again recently from the restructure) do let me know.
Oh also, what is with this new restructure? You go into phenethylamine’s and it’s just amphetamine and MDMA - c’mon now!
So I am working with phenethylamine’s and have made mescaline and reduced quite a few other nitroalkene’s with great yields.
I would like to make some 2c-e and given that I have 2,5-DMOBA, and I only want to make a small quantity so yield isn’t as important to me as flexibility, could I perform a Grignard ethylation on the 2,5-DMOBA?
I understand that people usually start from the acetophenone but I can only buy precursors in large amounts (well large in terms of what I actually need) and it doesn’t make sense to buy a load of that and start from that.
I would react 2,5-DMOBA with EtMgBr (probably as a premade solution) in an argon atmosphere, in an ice bath…
Is this something that is going to work? I’m a little worried about purification but figured the boiling point shouldn’t be radically different to the starting aldehyde - a little higher of course.
I dunno; 2c-e is something I REALLY want to make, iv not consumed any for YEARS (since 2000’s RC times) and it’s probably my favourite psychedelic - CERTAINLY my favourite phenethylamine so far…
I am obviously learning and I figured adding an extra step at the beginning of the process would make sense…
I did look into friedl-crafts alkylation but poo poo’d the idea. I’m sort of hoping this idea is AS MUCH of a poo poo.
As I say, I’m happy to get crap yields as I don’t need much anyway.
I also realised that it’s only when you haloginate at the 4 position, that the NaBH4 / copper catalysed reduction kicks it off - handy for me here…hopefully
If I AM being a mad amateur like a lot of my old posts on here are (which have all been bought up again recently from the restructure) do let me know.
Oh also, what is with this new restructure? You go into phenethylamine’s and it’s just amphetamine and MDMA - c’mon now!