A-PVP & Sleeping pills
A-PVP, or alpha-Pyrrolidinopentiophenone, is a synthetic stimulant drug that affects the central nervous system (CNS). A-PVP acts primarily by inhibiting the reuptake of certain neurotransmitters, specifically dopamine and norepinephrine. By blocking the reuptake of dopamine and norepinephrine, A-PVP increases their concentrations in the synapse, which is the small gap between two neurons. The increased levels of dopamine and norepinephrine result in amplified stimulation of their corresponding receptors in the brain. Dopamine is associated with pleasure, reward, motivation, and arousal, while norepinephrine is involved in alertness, focus, and the "fight or flight" response. The prolonged presence of these neurotransmitters enhances their effects, leading to heightened arousal, increased energy, euphoria, and a sense of confidence.
Sleeping medications, also referred to as hypnotics or sedatives, are commonly utilized to address sleep disorders like insomnia. Their primary function is to target various mechanisms within the body to facilitate sleep. There exist several categories of sleeping pills, each with distinct modes of action and potential side effects.
- Benzodiazepines (BZDs): Diazepam, Lorazepam, and Temazepam. BZDs intensify the impact of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. By inhibiting neuronal activity, GABA elicits a calming and sedative effect.
- Non-Benzodiazepine Hypnotics (Z-drugs): Zolpidem, Zaleplon, and Eszopiclone. Z-drugs also enhance GABA's effect but specifically target the GABA-A receptor subtype. They induce a similar sedative effect to BZDs while carrying a lower risk of dependence.
- Melatonin Receptor Agonists: Ramelteon and Tasimelteon. These medications imitate the actions of melatonin, a hormone naturally produced by the pineal gland that regulates the sleep-wake cycle. By binding to specific receptors in the brain, melatonin receptor agonists promote sleep.
- Orexin Receptor Antagonists: Suvorexant. Orexin is a neurotransmitter involved in promoting wakefulness. By blocking the action of orexin, these antagonists induce increased drowsiness and improved sleep.
- Antidepressants: Trazodone and Doxepin. Certain antidepressants, particularly those possessing sedating properties, are occasionally prescribed off-label to aid with sleep. They can impact neurotransmitters like serotonin and norepinephrine, which play a role in regulating sleep patterns.
- Over-the-counter (OTC) Antihistamine sleep aids: Diphenhydramine and Doxylamine. These products generally contain antihistamines that induce drowsiness. By blocking the effects of histamine, a neurotransmitter involved in wakefulness, they facilitate sleep.
We do not have accurate and reliable data on direct undesirable interactions and acute adverse reactions when combining A-PVP and sleeping pills. This does not mean that they cannot be.
The opposite effect of the components of this combination gives grounds to assume that joint simultaneous use will lead to blurred effects, difficulties in assessing one's condition, problems with orientation in space, time and one's own self.
There is a high probability of overdose if the hypnotic effect is suppressed for some time by a stimulant, and then it will fall on the CNS in full. This unfavorable scenario may result in sudden loss of consciousness, aspiration of vomit, comatose state.
There is also a possibility of developing paranoid states with a high degree of anxiety and malfunctions of the cardiovascular system. This is generally typical for A-PVP.
Particular caution should be exercised when combining A-PVP with a group of sleeping pills from the antidepressant range. They can increase serotonin levels. A-PVP acts mainly on the entrainment of dopamine and norepinephrine, however, to some extent and in an incomprehensible way, it can also increase serotonin levels. Therefore, there is a risk of developing serotonin syndrome.
On the other hand, with proper timing, the opposite of effects can be useful. So at the end of the action of A-PVP, sleeping pills can help with the relief of the exit state and post-effects in the form of insomnia, restlessness and tension of the central nervous system. In this case, it is necessary to wait for the decline of the main effects of the A-PVP and use the minimum working dosages of sleeping pills.
In light of these considerations, we strongly recommend a meaningful approach to this combination.
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