substitutes for CH3NH2 in reductive amination

[krillin]

Hi all,

my friend is wondering what are the lesser known substitutes for CH3NH2 in this step (for mdp2p). Someone heard that DMSO can be used, but it isn't seen as likely.

Thanks

 

[WillD]

Hello! not DMSO, formaldehyde can be used. look here (click). And u can use nitromethane in some cases (Al/Hg)

 

[krillin]

Thanks a lot!! Would it be useful in any part of the procedure at all (DMSO)? Like maybe only replacing dH2O with NaOH for a strong base?

 

[WillD]

Depending on what tasks, sodium hydroxide is not always suitable. DMSO is used as a medium to increase the basicity of potassium carbonate, for example.

 

[krillin]

Ok thanks a lot