Compared to the reduction of P2NP on aluminum amalgam, this method offers a significantly quieter reaction (The reaction isn't exothermic ), better yield (90%) and a very pure substance (no additional purification required).
Dissolve 15 g of P2N0 in 50 ml of anhydrous acetone
Place 100 ml round-bottomed flask on a magnetic stirrer equipped with a reflux condenser. Add acetone and 42 g of tin(II) chloride dihydrate
Turn on the stirring, wait for the tin chloride to dissolve and add the solution of P2NP in acetone
Stir for 20 minutes, the temperature rises slowly. A decrease in the temperature of the mixture indicates the end of the reaction. Place 150 ml of cold water and 4 ml 36% hydrochloric acid in a glass, slowly add to the mixture with stirring. The color of the solution changes
Prepare a solution of sodium hydroxide (200 g per 200 ml of water), cool it to room temperature and add to the mixture to pH>10 (in an acidic or neutral environment, extraction of oxime is impossible), a precipitate of inorganic salts immediately forms.
Extract 3 x 50 ml portions of ethyl acetate. dry with anhydrous magnesium sulfate. Place 60 ml glacial acetic acid in a beaker on a magnetic stirrer and add the solution that previously obtained (oxime in ethyl acetate).
While stirring, add 10 g of zinc dust.
Stir for 15 minutes.
Add a cooled solution of sodium hydroxide (50 g in 100 ml water) to pH>10.
Filter the mixture. add 50 ml dichloromethane, separate the organic layer, and additionally extract the aqueous layer 3 times with 20 ml DCM.
Organic extracts combined and dried over anhydrous magnesium sulfate.
We get a solution of 10 g amphetamine base in DCM. Add 50 ml of anhydrous acetone and the desired acid to obtain the corresponding salt.
