Desomorphine Synthesis Guide?

m03

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Anyone have a guide for the desomorphine synthesis + how to properly clean the substance afterwards? Not planning on producing on a large scale.
 

Hank Schrader

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I think that such information is not needed here. Desomorphine is very destructive to a person.
In any case, if you are not convinced ... then the synthesis is very simple.
Look at the reduction reaction of ephedrine with iodine and phosphorus.

You need to replace ephedrine with codeine and you will get desomorphine.
Phosphorus acts as a reducing agent in this reaction, and iodine is a catalyst and creates the acidic environment necessary for the reaction to proceed, in which your codeine turns into desomorphine ...
 

chemistrydude

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Desomorphine aka krokadil, it's pretty destructive opiod, that builds addiction very fast, and problems are getting worse and worse, your skin will turn into a crocadile, so that's dangerous.
 

m03

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ONLY if it isn't cleaned
 

chemistrydude

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I know, but still opioids are building big addiction.
 

m03

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Sorry for the stupid question but use the same weight of codeine as ephedrine?
 

Hank Schrader

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Calculate the reaction in molar ratio.
I don't know what codeine salt you have.
 

m03

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Sorry, I'm not very good at calculating molar ratios. I am gonna be starting this from codeine phosphorous
 

plancklong

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Would you care to back that up by showing the mechanism by which this happens? To my knowledge, the only working synthesis involves three steps:

1. Codeine is treated with thionyl chloride to yield a-chlorocodide
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2. a-chlorocodide is reduced (hydrogenated), giving desocodeine:

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3. Finally, the desocodeines remaining methoxy group is demethylated giving desomorphine:

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But hey, if there's a way to trim this down to 2 steps, or even one, I would be interested to see how that could happen!
 

m03

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I
disregard what i typed here before.
https://www.ojp.gov/pdffiles1/nij/grants/254755.pdf
look on page 36.. mentions the nagai method used by the russians
 

Hank Schrader

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Dozens of ways to get the same substance. Each method has its own mixins and markers. The easiest method in my opinion is iodine + red phosphorus.
You can use any method you feel comfortable with.
 

Cranston

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Desomorphin turns people into Crocodiles and Flakka turns them into face-eating zombies.
 

gfs241

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Desomorphine does destroy skin because people use a dirty product. The man who ate someone's face off that was supposedly on aPVP had nothing more than cannabis in his system.
 

Cranston

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If you combine those drugs, you become a face-eating crocozombie.
 

BobbyBaccalieri

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Ignore all these fuckin jerkoffs who think desomorphine is the same thing as krokodil. Just figure out solubilities of desomorphine, phosphorous acid, hydroiodic acid, and whatever else. Then find a the right solvent to extract the good stuff
 
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Cranston

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you do know that drugs are evil?
with crocodile you turn yourself into a green reptile and your flesh rots.
with flakka you turn yourself into a green zombie and you eat rotten faces.
using both a bad idea.
 
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Guucicicuci

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Dude the guy that ate someones face was already mentally ill and crocodile doesnt destroy your body. The damage is caused by those people injecting them selfs with promethazine, acids and other stuff. The streat synthesis of desomorphine is actually really interesting because it doesnt just produce desomorphine, the mex thats produced there contains many morphinians that arent even known.

https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/28708940/
page 22
 

HerrHaber

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I beg people to rather consider the first answer to this question and keep your mind occupied with something more constructive. If it no longer turns the user into a reptile it doesn't make it healthy or a good idea.
 
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